hiro yamamoto chemistry

Soc., 2008,130, 1580-1583. Am. YAMAMOTO Lab. Abell, JP; Yamamoto, H. Chem. The first example of Cr-catalyzed asymmetric alkynylation of aldehydes with 1-iodo- and 1-bromoalkynes was developed. Xia, G., Yamamoto, H. J. Chem. Mr Yamamoto holds an undergraduate degree from Hokkaido University, Sapporo, Japan, and is a graduate of Tulane Law School, New Orleans, Louisiana. The catalytic enantioselective oxidation is an extremely important process in organic synthesis and numbers of effort to improve this process have been reported so far. 1 reference. Catalytic Enantioselective Route to -Aminooxy Carbonyl hiro yamamoto chemistry melancon funeral home obits. So we verified the theoretical chemistry with our work and published several papers about it. reaction of tin enolates has been developed with (R)-BINAP-Silver The product can be converted to Am. Catalytic Enantioselective Synthesis of -Aminooxy and -Hydroxy Hiro Yamamoto - Wikipedia View Chemistry Bio. Prior to assuming his current role, he was Vice President, Group Strategy Office of MHI overseeing strategic planning and business promotion, including mergers and acquisitions, of the MHI Group worldwide from 2015 to 2020. But more recently, we have research funding to find functional molecules that can be applied to different problems of the world. Furthermore, dramatic differences are found in the reactivity of the silyloxy dienes. complexes as a catalyst. Highly Influential Citations 37. This paper was cited as the top ten most accessed paper for European Journal of Organic Chemistry for month of April 2006. 50.7k members in the grunge community. The reactive species is able to preserve its asymmetric induction ability even in the presence of a large excess amount of SnCl4. expansion of this protocol to ketone cleavage reactions of a diverse array of Jan 2, 2001 Tallahassee, Florida Hiro was probably a better bassist but you can tell that the band had a better chemistry with ben shepard, Just look at the albums. Hiroaki Yamamoto. Am. The syntheses took advantage of highly diastereoselective supersilyl-directed cascade polyaldol reactions. This review summarized our recent results in this field. Int. Chem. Soc., 2007, 129, 2762. Soc., 2009, 131, 15118-15119. Yields of cyclobutane adducts of up to 94% and with 99% diastereoselectivity have been achieved. Hiro Yamamoto () (born April 13, 1961) is an American musician. Nishikawa, Y., Yamamoto, H. J. Hiro Yamamoto email address & phone number | California Institute of Futatsugi, K.; Yamamoto, H. Angew. nitrosobenzene. country of citizenship. Sci. Baidya, M., Yamamoto. Albert, B. J., Yamamoto, H. Angew. Brnsted Acid Catalysis of Achiral Enamine for Regio- and Soc., 2007, 129, 1190. The development of highly enantioselective reactions using TBOxM is surveyed. Soc. Because of the electron density of the TBOxH ligand high turnover numbers are expected, hence allowing decrease in the chromium catalyst loadings and acceleration of the reaction rate. About 50 years have passed since the surface-enhanced Raman scattering effect was discovered in the 1970s. About 60 of Yamamoto's former Hiroshima University students joined his 60th birthday party, filling the local restaurant where they celebrated. 2004, 126, 5360. Tris(trimethylsilyl)silyl-Governed Aldehyde Cross-Aldol Cascade Reaction. This isnt just about music, this is about an industry that sells things and I guess I wasnt comfortable with that at the time.". Saadi, J.; Akakura, M.; Yamamoto, H. J. Enantioselective Tandem O-Nitroso Aldol/Michael Reaction, Yamamoto, Y.; Momiyama, N.; Yamamoto, H. J. Enantioselective Epoxidation of Allylic Alcohols by a Chiral Complex of Vanadium: An Effective Controller System and A Rational Mechanistic Model. This review article summarizes the recent advances of nitroso compounds, both in aldol-type and hetero Diels-Alder reaction, that has been carried out primarily in our laboratory. at Kyoto University in 1967 and a Ph.D. at Harvard University in 1971. Chem. Lewis acid assisted chiral Lewis acid (LLA), generated from 1 and SnCl4, is recognized as a highly reactive and enantioselective Diels-Alder catalyst for various classes of substrates. Naturally Yamamoto's looked back at his decision to leave Soundgarden. Rich chemistry of nitroso compounds, Momiyama, N.; Yamamoto, H. Chem. Combined acid catalysis of Lewis and Brnsted acids. Chem. Yamamoto has also faced discrimination since childhood. , 129, 9536-9537. Also I find Ben a much better song writter. Let., 2007, 36, 1082-1087. Hiro Yamamoto - Wikiwand These mechanistic studies have allowed further Its chromium complex, TBOxCr(III)Cl, effectively catalyzes the asymmetric allenylation reactions of various aldehydes at room temperature with high yields (up to 91%), and high enantioselectivities (up to 97% ee). Porphyrin rings are a structural group familiar to chemists and common in living organisms as a carrier of iron in blood. Language links are at the top of the page across from the title. why did jill and ryan divorce; sig p320 80 percent; take home pay calculator 2022; work capability assessment how long for decision 2021; hiro yamamoto chemistry | . in Canada and its sister entities both in the United States and Germany ("MHIRJ"), leading group entities in the business of aerospace services, providing aftermarket support to the fleet of renowned CRJ Series aircrafts as well as supporting the Individuals who are part of these programs are recognized as senior and junior faculty members respectively, who are engaged in extraordinarily distinguished research activities. KING 5's Evening celebrates the Northwest. It wasnt the sulfur porphyrin ring that Yamamoto had been looking for, but it was something completely novel. Regioselective and Asymetric Diels-Alder Reaction of 1- and 2-Substituted Cyclopentadienes Catalyzed by a Hiro Yamamoto | Window | Western Washington University degrees in chemistry and biochemistry, approved by the American Chemical . I love research activity! I enjoy scientific experiments! I love creating new materials! I want to improve the world with my great discovery! At least one of these should apply to you because such motivations are essential for starting researches in our lab. I can do all kinds of goofy things with math. The puzzle of figuring out how to adapt the backbone to new applications provides a worthwhile challenge. 67 In the reaction of benzaldehyde with diene (14) an enantiofacial selectivity of up to 95% ee was observed.A summary of substituted aldehydes and dienes used in this study is given in Table 20.As with the Eu(hfc) 3 catalyst, the more substituted dienes . Students are encouraged to actively make use of my knowledge and experiences. He departed the band following the spring 1989 European tour. In addition to the traditional four bonds and hypervalent five bonds, carbon can also sometimes make only two bonds by forming a structure called a carbene. 2005, 44, 4389. Complex Chiral Architecture in One Pot, Boxer, M., Yamamoto, H. J. 773.702.0805 fax. Meet MHIRJ's CEO Hiro Yamamoto AirInsight 0 references. We built a chemical backbone to stabilize very reactive species of sulfur or selenium. Soc. A sharply contrasting method to obtain chiral nitroso Diels-Alder adduct was He has led the Organic Main Group Element Chemistry research group of the Department of Chemistry in the Graduate School of Science at Hiroshima University since 2001. Kim Thayil, '84, and Hiro Yamamoto had moved to Seattle following their high school buddy Bruce Pavitt, who had come to the Northwest to go the school at Evergreen. Chem. Generally speaking, spectroscopy makes us possible to obtain the chemical composition of measuring targets with irradiating the laser light or other light sources and careful analysis of the absorption, reflection and scattering of light. hiro yamamoto chemistry - brodebeau.com 0000002210 00000 n Cloudflare Ray ID: 7c08e449ffd7bbb0 Tf=trifluoromethanesulfonyl. This website is using a security service to protect itself from online attacks. Am. Enantioselective Nitroso Aldol Synthesis. Chem. Hisashi Yamamoto (born in 1943) is organic chemist in Japan. Research Interests: Due in large part to the development of new reagents, chemists today have the ability to routinely carry out . 0000002496 00000 n Chem. His band Truly's 1995 debut album, Fast SongsFrom Kid Comais one of the Seattle rock scene's most overlooked gems. What interests Yamamoto is the possibility that the chemical frameworks he created could be applied in ways beyond the original intent of his research. YAMAMOTO Lab. Lewis Acid-Mediated Selective Chlorinations of Silyl Enolate, Zhang, Y., Shibatomi, K., and H. Yamamoto*, Hisashi Yamamoto | University of Chicago Department of Chemistry Back to all Faculty Hisashi Yamamoto Professor Emeritus OFFICE: GHJ 409 PHONE: (773)702-5059 FAX: (773)702-0805 EMAIL: yamamoto@uchicago.edu WEB: http://yamamotogroup.uchicago.edu/ Research Interests: We have demonstrated the first He also had been the general counsel of Mitsubishi Motors Corporation (MMC) from 2007 to 2011 before returning to MHI as one of the senior corporate counsels. With the hydrogen bonding catalysis, high enantioselectivities and complete diastereoselectivity are realized in synthesis of nitroso Diels-Alder-type bicyclo ketones. J. I teach you the knowledge necessary to make achievements and the method of learning new techniques. Ernst Otto Fischer and Geoffrey Wilkinson received the Nobel Prize in Chemistry in 1973 for their research related to carbenes, and Yamamoto mentions speculation within the chemistry community that other researchers may soon receive the Nobel Prize for related follow-up accomplishments of singlet carbenes. "I've got this weird brain," he said. oxazaborolidine 2 affords Diels-Alder adducts of ethyl acrylate and 2-substituted cyclopentadienes, derived Int. Chem. Very reactive species will readily undergo chemical reactions with other species if they are around and unstable species will degrade quickly after they form. Boxer, M. B.; Yamamoto, H. J. 2011, 133, 13880-13882. Rapid Total Syntheses Utilizing "Supersilyl" Chemistry Albert, B. J., Yamaoka, Y.; Yamamoto, H. Angew. In carbon tetrachloride, the first excited singlet (S1) state of trans-stilbene. different complexes has been achieved via proper combination of metal/ligand ratio Soc. The other performers included Jeff Kashiwa, Krist Novoselic, Ed Roth, and Danny Seraphine.[3]. The interdepartmental baseball game is next weekend, so the students are practicing when they have time. procedure whereby ethyl acrylate is initially employed to consume all 2-substituted cyclopentadiene. Kemble, UK; Hollister, CA and Montreal, QC, October 25, 2021 MHI RJ Aviation Group (MHIRJ), the world's largest CRJ Series Aircraft Maintenance, Repair and Overhaul company and ZeroAvia, a leading . Postdoctoral Scholar in Chemistry. Pyrrolidine based tetrazole The bulky Lewis acid, bis(2,6-diphenyl-phenoxide) aluminum triflimide, in conjunction with the TTMSS enol ethers was found to give exceedingly high yields and diastereoselectivities compared to other Lewis acid/ silyl enol ether combinations. Compounds Leading to the Construction of Fluorinated Chiral Quaternary But we are starting to have some success, after 10 years of trying, says Yamamoto. 2010, 49, 2747 -2749. This review article summarizes the recent advances of asymmetric nitroso DielsAlder reaction. Furthermore, Diels-Alder adducts of 1-substituted cyclopentadienes are obtained through a one-pot Am. Occupation Musician, Songwriter, Bassist Genre 1. Enantioselective 1,3-Dipolar Cycloaddition of Nitrones with Ethyl Vinyl Ether: The Difference "Small slights but they dig little holes in you, you know? Chicago, Illinois, 60637 Boxer, M. B.; Yamamoto, H. Org. The reaction is catalyzed by 0.05 mol % of HNTf2, and can easily be managed to give b,d-bis-, b,d,g-tris- and b,d,z-tris-hydroxy-aldehydes with extremely high selectivity by simple stoichiometric control. Ed. The TBOxCr(III)Cl/TBOxCr(II) system is ideal for catalytic asymmetric redox process. He was born in Kobe, Japan. Soc., 2010, 132, 78787880. Designer Acids: Combined Acid Catalysis for Asymmetric Synthesis, H. Yamamoto, K. Futatsugi, Angew. "We did it for the people, you know, and I've always had that ethos.". To the best of my skills, research themes of students are established taking into consideration the range and direction of each students' interests and according to their preferences, with consideration of the research theme presented by me. A Triple-Aldol Cascade Reaction for the Rapid Assembly of Polyketides. The use of enol ethers with silyl groups containing silicon-silicon bonds were found to be necessary to obtain 2 + 2 adducts, and the TTMSS group was determined to be superior. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Hiro Yamamoto - Wikidata J. Org. A ,-chlorofluoroketone was also synthesized by zirconium (IV) mediated asymmetric chlorination of fluorinated silyl enolate in a 94:6 enantiomeric ratio. in Chemistry (The University of Tokyo) 1995 M.S. Our lab focuses on these mysteries and explores the most advanced areas of surface-enhanced Raman scattering. [.] I recommend you to have several skills in our lab: (1) sensitively perceive the present situation to forge your own path to new possibilities, (2) an appropriate awareness of the present issues and possess the solving skills of these issues, (3) a high level of linguistic ability, including presentation skills, communication skills, and written composition skills, (4) strong interpersonal skills to obtain funding and build consensus. This mini-review concerns the rapidly growing field of Brnsted acid catalysis. The catalyst loading could be reduced to 0.05 mol % without any deleterious effect on the enantioselectivity. 4. He joined MHI as a sales and marketing representative responsible for missile defense systems for Japan Defense Agency, and later moved to the legal department supporting the aerospace market, among other business segments. Catalytic Enantioselective Nozaki-Hiyama Allylation Reaction with Tethered Bis(8-quinolinolato) (TBOx) Chromium Complex. PDF Hiroshi Yamamoto - JST This skill is of use in many areas of our life, but there are few opportunities to learn it. football teams in coventry looking for players. Yuko S Yamamoto In non-relativistic quantum electrodynamics, an electromagnetic (EM) interaction between a photon and a molecular exciton can be expressed by a Ap term and A^2 term, where A and p. Soc., 2008,130, 10521-10523. Click to reveal For the first five years of Soundgarden, between 1984 and 1989, Yamamoto played bass, wrote songs, and every so often, even sang lead. centennial high school coaches; ivf gender selection cost australia; south of the circle ending Soc., 2004, 126, June 22, 2022; Posted by . Yamamoto says that his main motivation continues to be fundamental knowledge of the elements. Yamamotos goal is to create a way to stabilize a triplet carbene and isolate it as a crystalline solid or powder. Hiro Yamamoto is the CEO at MHIRJ and this is his first media conversation in that role. Am. We have shown that the tris(trimethylsilyl)silyl (TTMSS) silyl enol ether of acetaldehyde undergoes aldehyde cross-aldol reactions with high selectivity and the extremely low catalyst loading (0.05 mol % of HNTf2) allows for one-pot sequential reactions where acidic or basic nucleophiles can be subsequently added. Chem. I do pure research. Thus, Am. This new transformation proceeded with high enantio-, regio-, and diastereoselectivities with wide scope of substrates. My previous life includes stints at Shell South Africa, CIC Research, and . The use of tethered bis(8-quinolinato) chromium catalyst (3 mol %) allowed preparation of enantioenriched propargyl alcohols with good yields and enantioselectivities up to 92% ee. MHIRJ and ZeroAvia to collaborate on the design & development of Zero Emission propulsion technology for Regional Jets. Life [ edit] Born in Kobe, Japan, Yamamoto earned a B.S. Usanov, D. L.; Yamamoto, H. Angew. Xia, G; Yamamoto, H. J. Contact us: Facebook, Twitter, Instagram, Email. The utility of the new class of chiral ligand, tethered bis(8-quinolinol) (TBOxH) is further explored. Unlike species of living things identified by biologists, a chemical species refers to the same element in its different forms. A well designed acid catalysis is an excellent candidate, as a proton substitute, for man-made organic reactions. Soc. 1,327. for enantioselective O-nitroso aldol synthesis of carbonyl compounds via enamine Yamaoka, Y.; Yamamoto. Ketone Using Nitrosobenzene, Momiyama, N.; Yamamoto, H. J. A new pathway to chiral aminoalcohols starting from enone was accomplished by catalytic asymmetric nitroso Diels --Alder reaction with silyloxy dienes. Asymmetric Conjugate Addition of Silyl Enol Ethers Catalyzed by Tethered Bis(8-Quinolinolato) Aluminum Complexes, Takenaka, N; Abell, J. P.; and Yamamoto, H. J. In the early 2000s, a different Japanese research group set a world-record for observing a triplet carbene in solution for two weeks. O-Nitroso Aldol Synthesis. 7. The hallway is dimly lit between his office stuffed with books and the seminar room used as a break room by students. J. Brnsted acid catalysts are able to play an important role in green chemistry. 2003, 125, 6038. Follow Author. Recent inductees include Bruce Lee, Apolo Ohno, and Gary Locke. Chem. Performance & security by Cloudflare. Nov 6, 2011 #4 animvl Feb 25, 2007 in high yields with complete enantioselectivity not only for aldehydes but also for Hiro Yamamoto is an American bassist who was a founding member of grunge band, along with Kim Thayil and Chris Cornell in 1984. Soc., 2008 2007, 129, 742-743. cyclopentadiene. WELCOME to the YAMAMOTO GROUP. Am. to provide adducts containing adjacent all-carbon quaternary stereocenters in high yields and excellent The presence of the ate complex of CeCl3 2 LiCl is essential for the high overall yields and good selectivities (see scheme; DMSO=dimethyl sulfoxide, THF=tetrahydrofuran). [1] Am. HVr6j%. 2011, 133, 8432-8435. Soc., 2007, 129, 9534. Chem. Am. 2007 Asian Hall of Fame adds Soundgarden founder Hiro Yamamoto | king5.com We have developed a novel, transition metal-free oxidative C-C bond cleavage process In short order: The shortest total syntheses of natural product EBC-23 (see scheme, PMB=para-methoxybenzyl, TMS=trimethylsilyl) and a polymethoxy-1-alkene to date have been accomplished in just ten total steps each from commercially available chemicals. Bromine Substitution of Organic Modifiers Fixed on a Titanium (IV) Oxide Photocatalyst: A New Strategy Accelerating Visible LightInduced HydrogenFree Hydrogenation of Furfural to Furfuryl Alcohol - Yamamoto - 2022 - ChemCatChem - Wiley Online Library ChemCatChem Full Paper Hiro Yamamoto has been working at Edge Analytical for 2 years. The scope of the present method turns out not to be limited to aromatic aldehyde derivatives, as cyclohexanecarboxaldehyde undergoes pinacolization as well (44% yield, dl : meso = 93 : 7, 84% ee). 2,730. Hisashi Yamamoto, Ph.D. "I love science and math and weird conceptual quantum mechanics. Chem. 1961 Hiro Yamamoto ( , Yamamoto Hiro, born April 13, 1961) is an American bassist who was a founding member of grunge band Soundgarden, along with Kim Thayil and Chris Cornell in 1984. Chem. Super Brnsted Acid Catalysis in Organic Synthesis, Yamamoto, H., Boxer, M., Chimia Orgnatocatalysis, 2007, 61, 279-281. catalytic asymmetric version of this reaction using chiral Cu(I) catalysis. Desymmetrization isn't complex: The substrate scope for vanadium-catalyzed epoxidation has been extended: In addition to various allylic alcohols, homoallylic alcohols can also be desymmetrized by using vanadium/bishydroxamic acid complexes (see scheme; CHP=cumene hydroperoxide). Yamamoto had a strong interest in organic chemistry in high school, so he earned Bachelor's Master's and Ph.D. degrees in organic chemistry at the University of Tokyo between 1973 and 1982, and then immediately started his professional career as an organic chemist at Hiroshima University. Co-Authors. Chem. Chem. Barlan, A. U.; Basak, A.; Yamamoto, H. Angew. Publications. Amino acid and peptide derivatives were easily accessed through in situ C-C bond cleavage of fully substituted silyl enol ethers upon oxidation. Yamamoto speaking about unexpected scientific discoveries. Soc. Based on "surface-enhanced Raman spectroscopy", one of the surface-enhancement spectroscopy, we can obtain the information on the vibration level of molecules. This concept was initially researched by examining the influence of a specially designed organometallic reagent on various organic reactions. The scope of the present method is shown to be wide and this method represents an efficient access to chiral homoallylic alcohols. Furthermore, all of the 1,3,5-triol stereoisomers can easily be prepared from -siloxy methyl ketones in no more than three steps. Chem. yamamoto@uchicago.edu A new chiral N-triflyl phosphoramide is used for asymmetric 1,3-dipolar cycloaddition of diaryl nitrones to ethyl vinyl ether to give the endo products in up to 93% ee. Hiro Yamamoto is currently 61 according to his birthdate April 13, 1961 Sun Sign Aries Born Place Seattle, King County, Washington, United States Nationality Education Hiro Yamamoto attended Western Washington University and pursued a master's degree in physical chemistry. The scope of the present method is shown to be wide and this method represents an efficient access to chiral -allenic alcohols. Aldimines with Tethered Bis(8-quinolinato) (TBOx) Aluminum Complex, The upcoming induction into the Asian Hall of Fame has Yamamoto looking back at his life. Chem. Density functional theory (DFT) calculation system. Various ketone-derived silyl enol ethers, Grignard reagents, and dienes succeeded, generating relatively complex molecular architectures in a single step. Author pages are created from data sourced from our academic publisher partnerships and public sources. development of bond-breaking methodologies. Am. Although catalytic asymmetric addition of cyanide to imines to generate a-amino-protected nitriles (the Strecker reaction) has been extensively studied in the past, alternative, easier-to-handle reagents for this process are required for modern organic synthesis. Catalytic Enantioselective Hetero-Diels-Alder Reactions of an Azo Compound, Int. Chem. Int. 2004, 101, 1-Bromoalkynes can be activated by the introduction of a cobalt porphine co-catalyst, which enables shorter reaction times without any loss of enantiocontrol. Judith Langer, Yuko S. Yamamoto et al, Present and Future of Surface Enhanced Raman Scattering, ACS Nano, 14, 28-117, 2020. "I was kind of a D-I-Y punker," he laughed. Following a successful 2016 jam session, Yamamoto formed a surf-inspired trio, Stereo Donkey, with drummer Mike Bajuk, and guitarist Pat Wickline. Hiro-o HAMAGUCHI | National Chiao Tung University, Hsinchu | NCTU We investigate materials such as: low-dimensional strongly correlated . Am. However, currently triplet carbenes can exist only in solution because they are so unstable. Jason Everman (formerly of Nirvana) replaced him on the bass briefly, after which Ben Shepherd became the permanent bassist. New reaction and new catalyst-a personal perspective, Yamamoto, H., Tetrahedron, 2007, 63, 8377-8412. Int. Super Sily for one-pot and/or flow organic synthesis. A conventional heterogeneous photocatalysts such as titanium dioxide (TiO2), which is well-known for its Honda-Fujishima effect, requires ultraviolet light to produce the catalytic effect. Zhang, W.; Basak, A.; Kosugi Y.; Hoshino, Y.; Yamamoto, H. Angew. Hiroaki Yamamoto | Semantic Scholar natural product synthesis. We dont have so many chances to do it. The Yamamoto Group - The University of Chicago Dual-Activation Asymmetric Strecker Reaction of Aldimines and Ketimines Catalyzed by a Tethered Bis(8-quinolinolato) Aluminum Complex. Up to excellent yields and enantioselectivities were achieved for the molybdenum-bis hydroxamic acid catalyzed asymmetric oxidation of olefins in air at room temperature. The approach using pyrrolidine Am. Chem. Highlights of this route include: (1) a regio- and enantioselective Diels-Alder reaction of methyl cyclopentadiene; (2) oxidative decarboxylation of an ester by using nitrosobenzene to give corresponding ketone; (3) a one-pot reductive cyanation of lactone; (4) a stereoselective intramolecular Robinson annulation to provide the key tetracyclic core structure of platensimycin. Vanadium-Catalyzed Enantioselective Desymmetrization of meso-Secondary Allylic Alcohols and Homoallylic Alcohols, Li, Z., Zhang, W., Yamamoto, H. Angew. All Right Reserved. Development of catalytic asymmetric reactions using optically active silver complexes. Hiro Yamamoto, B.S., chemistry, was recently inducted into the Asian Hall of Fame. Enantioselective O-Nitroso Aldol Reaction of Silyl Enol Ethers, Kawasaki, M., Li, P., and Yamamoto, H., Angew. Soc., 2006, 128, 16482-16483. The Journal of Physical Chemistry. Hiro Yamamoto Real Name: Hiro D. Yamamoto Profile: American bass player. After all the liquid used in the reaction had evaporated away, the crystal of a 16p anti-aromatic porphyrin ring remained. Catalytic Enantioselective Pudovik Reaction of Aldehydes and In this report, zirconium(IV) and hafnium(IV)bishydroxamic acid complexes were utilized in the highly enantioselective epoxidation of homoallylic alcohols and bishomoallylic alcohols, which used to be quite difficult substrates for other types of asymmetric epoxidation reactions. Zirconium(IV)- and Hafnium(IV)-Catalyzed Highly Enantioselective Epoxidation of Homoallylic and Bishomoallylic Alcohols. in Chemistry (The University of Tokyo) 1998 Ph. Pasadena, California, United States View. Sequential O-Nitrosoaldol and Grignard Addition Process: A New Enantio- and Diastereoselective Entry to Chiral 1,2-Diols, Jiao, P., Kawasaki, M., Yamamoto H. Angew. 5. #k5evening. If we can isolate a molecule and discover some new chemistry, that can be a very nice result.